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Zhiyong Zou

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Open access Sep 2026

NexuST: A Hierarchical Foundation Model for Spatial Transcriptomics

Spatial transcriptomics captures molecular states within cells and their organisation in tissue. However, integrating fine-grained gene information with spatial context at scale remains challenging for existing foundation models. Here we present NexuST, a hierarchical foundation model that repeatedly interleaves gene-l...

Hai-Ping Liu, Qian Zhao, Li-Jing Lin et al. · 0 citations
Review Open access Jul 2026

Foundation models in omics research: a comprehensive survey

This review systematically analyzes the emerging landscape of FMs in omics research, spanning sequence modeling, cell state characterization, and multimodal integration, and proposes a roadmap for the next generation of FMs, advocating for architectures that move beyond statistical correlation to incorporate causal rea...

Haozhe Liu, Wenhao Cai, Yizheng Sun et al. · 0 citations

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