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Author

Zhi-Xiao Li

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2 papers indexed here

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Review Open access Sep 2026

Deep brain stimulation mechanisms in comorbid pain and emotional dysregulation from animal models

This mechanism-based framework outlines a translational roadmap for personalized neuromodulation, guiding symptom-specific target selection and the development of biomarker-driven, closed-loop DBS systems to concurrently treat pain and affective pathologies.

Tian-En Si, Hao Han, Ying-Ying Zhang et al. · 0 citations
Aug 2026

Glutamatergic neurons in the nucleus accumbens represent a distinct functional population that gates pain.

BACKGROUND The nucleus accumbens (NAc) integrates affective and sensory information crucial for pain processing. While canonically viewed as a predominantly GABAergic structure, the potential existence and function of non-canonical excitatory populations remain poorly understood. We hypothesized that a distinct subpopu...

Tian-En Si, Zhi-Xiao Li, Ying-Ying Zhang et al. · 0 citations

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