Zhi-Wei Guan

An FDA‑approved dicarboxylic acid allosterically targets PNPLA3 to resolve osteoarthritis.

Osteoarthritis (OA) lacks disease‑modifying therapies. The infrapatellar fat pad (IPFP) is hypothesized to regulate joint metabolism, but its molecular effectors are unknown. We investigated whether IPFP‑derived metabolites protect cartilage via lipid‑metabolizing enzymes. METHODS Non‑targeted metabolomics, IPFP exci...