Erythrocyte-membrane camouflaged manganese dioxide-polydopamine nanocarriers for doxorubicin delivery and MRI-visualized chemo-photothermal cancer therapy.
Doxorubicin (DOX) chemotherapy is limited by systemic toxicity, poor tumor accumulation, and the acidic, hypoxic tumor microenvironment (TME). We developed MnO2-PDA-DOX@RBC/FA/PEG nanoparticles by coating manganese dioxide (MnO2) cores with polydopamine (PDA) for DOX loading and cloaking the particles with folic acid (...