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Author

Zhi-Ru Liu

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Open access Oct 2026

Recombination shapes the dynamics of selective constraint in global populations of human gut bacteria

The ratio of nonsynonymous to synonymous substitutions (dN/dS) encodes important information about the selection pressures acting on protein-coding genes. In bacterial populations, dN/dS often declines with the sequence divergence between strains, but the mechanisms responsible for this broad empirical trend are still...

Zhi-Ru Liu, Benjamin H. Good · 0 citations
Aug 2026

Functional characterization of Bcl-2-related ovarian killer (Bok) in apoptosis and antibacterial immunity in Trachinotus ovatus.

Bok (Bcl-2-related ovarian killer) is a pro-apoptotic member of the Bcl-2 family that plays a critical role in the intrinsic apoptotic pathway in mammals. However, its functional characterization in teleost fish remains largely unexplored. In this study, we identified and characterized TroBok, a Bok ortholog from golde...

Zhen-Jie Cao, Zhi-Ru Liu, Jing Zhang et al. · 0 citations
Aug 2026

Molecular characterization and heterodimerization of three type I interferon receptor subunits (CaCRFB1, CaCRFB2, CaCRFB5) in the humpback grouper (Cromileptes altivelis).

These results validated the canonical heterodimerization of the short-chain CaCRFB5 with both long-chain subunits (CaCRFB1 and CaCRFB2) as well as a noncanonical interaction of CaCRFB1/CaCRFB2, suggesting a more intricate receptor pairing in teleosts.

Han Zhang, Ting Wu, Ying Chen et al. · 0 citations

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