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Identification of Gene Signatures and Molecular Mechanisms Underlying the Comorbidity of Alzheimer's Disease and Crohn's Disease Using Machine Learning.
OBJECTIVE Alzheimer's disease (AD) and Crohn's disease (CD) both involve inflammation and immune dysregulation, yet the potential molecular mechanisms underlying their comorbidity remain unclear. METHODS We integrated transcriptomic data from AD and CD patients and applied differential expression analysis, weighted g...
Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p‑tau181 levels in mild cognitive impairment
The role of complement in Alzheimer's disease (AD) remains unclear, particularly regarding tau pathology and memory decline.