Sep 2026
Discovery of Arginine-Reactive Covalent Kinase Inhibitors Overcoming Clinical Drug Resistance
This work expands the CKI toolbox to include arginine-targeting warheads and provides a modular framework to overcome point mutation-driven resistance, and provides a modular framework to overcome point mutation-driven resistance.
Zu-Qin Wang, Xuan Wang, Hong Zhang et al.
· Journal of Medicinal Chemist... · 0 citations