Zhi-Li Liu

AURKA phosphorylation licenses TRIM28-dependent SUMOylation to stabilize SPICE1 in prostate cancer bone metastasis

Bone metastasis is a major cause of disease progression and cancer-related death in advanced prostate cancer (PC). Although spindle and centriole associated protein 1 (SPICE1) has been implicated in tumor biology, its role in PC metastasis and its post-translational regulation remain largely unknown. SPICE1 expression...

PLPP1 inhibits Wnt/β-catenin signaling via enhancing Caveolin-1/β-catenin interaction and is negatively regulated by c-Myc in osteosarcoma

Background Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents, characterized by rapid progression and poor prognosis. The molecular mechanisms underlying OS malignancy remain incompletely understood. Phospholipid phosphatase 1 (PLPP1) has recently been implicated in cancer biology, yet its...

A novel classification of patients with cervical spinal cord injury without fracture-dislocation based on imaging features: a multicenter study

A novel classification of CSCIWOFD based on preoperative cervical spine X-rays, computed tomography (CT), and magnetic resonance imaging (MRI) characteristics was developed based on patients with CSCIWOFD, which was proven to be reliable.

Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures