Zhi-Hong Wang

Kinetic signatures of RAS-BRAF engagement reveal isoform selectivity, oncogenic amplification, and mutation-dependent inhibitor resistance.

The RAS-RAF-MEK-ERK (MAPK) signaling cascade is a central regulator of cellular proliferation and differentiation, and its dysregulation is a frequent driver of oncogenesis. RAF activation requires recruitment by GTP-bound RAS at the plasma membrane; however, the precise molecular determinants governing RAS-RAF engagem...