Metabolite-Driven Immunosuppression in High-Risk NSCLC — with Anti-Tumor Immunity Shaped by Probiotic Strategy, Donor Origin, and Conserved Microbial Mediators
Elevated serum cytokeratin 19 fragment (CYFRA 21-1) in non-small cell lung cancer (NSCLC) links to immunosuppression, but whether live gut bacteria or their metabolites mediate this effect remains unclear. Using stratified fecal microbiota transplantation in a Lewis lung carcinoma model, we demonstrate that cell-fr...