Open access
Aug 2026
Chrysosplenetin-induced TMED3 aggregation triggers unfolded protein response in pancreatic cancer
Pancreatic cancer (PC) continues to demand urgent therapeutic innovation given its limited treatment options. Here, through phenotypic screening of a natural product library followed by systematic validation, we identified chrysosplenetin (CHR) as a bioactive compound with anti-PC activity. Transcriptomic profiling and...
Zhe Zhang, Ning-Na Weng, Xuan-Hao Gu et al.
· EMBO Molecular Medicine · 0 citations