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Author

Zhi-Hao Guo

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2 papers indexed here

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Open access Sep 2026

Chemically Induced Proximity for Targeted Protein O- GlcNAcylation

O-GlcNAcylation is a ubiquitous post-translational modification across the mammalian proteome, yet determining how individual O-GlcNAcylation events control specific protein functions remains a central challenge. The O-GlcNAc cycle is governed by two enzymes: O-GlcNAc transferase (OGT), which installs O-GlcNAc, and O...

Bo-Wen Ma, Tong-Yang Xu, Zhi-Hao Guo et al. · 0 citations
Sep 2026

Targeted O-GlcNAcylation enables functional rewiring of c-Myc.

An O-GlcNAcylation-targeting Chimera (OGTAC) is developed that recruits O-GlcNAc transferase (OGT) to the oncogenic transcription factor c-Myc, enabling targeted O-GlcNAcylation in living cells without globally perturbing cellular O-GlcNAcylation.

Tong-Yang Xu, Zhi-Hao Guo, K. S. Khan et al. · 2 citations

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