Open access
Aug 2026
SESN2 promotes ferroptosis in bladder cancer by negatively regulating the NRF2/FSP1 signaling axis
Background Bladder cancer (BLCA) shows intrinsic ferroptosis resistance. Sestrin2 (SESN2) regulates ferroptosis in other diseases, but its role in BLCA is unknown. In this study, we sought to determine whether SESN2 contributes to the intrinsic ferroptosis resistance of BLCA and to elucidate the underlying molecular me...
Jian-Fen Hu, Yang-Ming Wang, Yong-Hui Du et al.
· Translational Andrology and... · 0 citations