Zhi-Gang Xiong

Alternative splicing in Alzheimer's disease: event-level evidence, risk-locus biology, and RNA-based therapeutic perspectives.

Genetic and transcriptomic studies have identified many Alzheimer's disease (AD) risk loci, but many remain difficult to interpret at the level of gene expression alone. Alternative splicing (AS) provides an event-level framework for linking genetic variation, transcript architecture, RNA surveillance, and protein-doma...