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The catalytic core of DNAzymes is highly sensitive to local structural perturbations. Conventional DNAzyme-based SNV sensing mainly relies on differences in hybridization stability between matched and mismatched targets. Here, we position the SNV immediately adjacent to the catalytic-core reconstitution junction of a...
A DNA nanodevice that anchors to cell membranes and releases chemotherapy only when three specific cancer markers are detected simultaneously is developed, establishing a versatile platform for logic‑controlled, multimarker‑guided cancer theranostics.
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