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Zhi-An Huang

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#artificial intelligence Preprint Oct 2026

PharmAgent: Constraint-Aware Search with Frozen Language Models for Molecular Optimization

The exact identity that characterizes how accepted-state violations accumulate in the controller's multipliers is derived, and the full system leads every ablation variant in target quality, property-adjusted performance, and Pareto hypervolume.

Ni-Hui Shao, Guan-Xing Chen, Ji-Long Shi et al. · 0 citations
Book Open access Aug 2026

Multi-Hop Diffusion-Wavelet Semantic Learning for Zero-Shot Circrna-Mirna Interaction Prediction

This paper proposes BioWave, a multi-hop diffusion-wavelet model that learns both structural and semantic representations for accurate CMI prediction and achieves superior performance compared to state-of-the-art baselines, particularly in zero-shot settings.

Mengmeng Wei, Lei Wang, Peng-Wei Hu et al. · 0 citations
#machine learning Preprint Sep 2026

More Sensors Only One Field: Rethinking Continual Spatio-Temporal Forecasting

Continual spatio-temporal forecasting supports traffic management and environmental monitoring under evolving dynamics and expanding sensor networks. However, conventional graph-based continual learning methods tie forecasting representations to the current sensor layout, so sensor expansion can alter the representatio...

Le-Wei Xie, Hao-Yu Zhang, Jia-Jun Zhou et al. · 0 citations
Sep 2026

ScGraphTrans: Pathway-Guided Graph Learning and Domain Adaptation for Cell Type Annotation in Single-Cell RNA-seq.

ScGraphTrans, a graph neural network framework that integrates functional state pseudo-labels, graph structure learning, and graph domain adaptation to improve both cell type annotation and communication inference, is proposed, offering insights into biomarker discovery and therapeutic strategies.

Yue-Chao Li, Hai-Ru You, Meng-Chao Wei et al. · 0 citations
Jul 2026

Functionally Guided Graph Learning for Robust Cross-Patient Cell-Type Annotation in Single-Cell RNA Sequencing

Experiments on three cross-patient scRNA-seq data sets demonstrate that PathoGraph achieves stable annotation performance across 32 directed reference-to-query transfer tasks, showing competitive and stable performance compared with representative marker-based, correlation-based, and model-based annotation methods.

Yue C. Li, Mengmeng Wei, Xinfei Wang et al. · 0 citations

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