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Molecular design and delivery of extracellular and membrane protein degradation chimeras.
Extracellular and membrane-associated proteins constitute a substantial therapeutic target space that remains largely inaccessible to intracellular degradation strategies based on the ubiquitin-proteasome system. Membrane and extracellular targeted protein degradation (meTPD) addresses this limitation by coupling targe...
The design of activatable photosensitizers and applications in precision immunomodulation.
This review systematically elaborates on the molecular design principles of activatable photosensitizers and their recent advances in precise immunomodulation for cancer therapy, and delves into the underlying mechanisms by which activatable photosensitizers synergistically potentiate anti-tumor immune responses.