Author

Zhenye Shi

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Open access Sep 2026

Combined HMOs and α-MFGM Ameliorate LPS-Induced Intestinal Mucosal and Systemic Immune Dysfunction via Modulation of Gut Microbiota

Background: The intestine functions as the body’s primary immune barrier, playing a vital role in host defense against pathogens. Human milk oligosaccharides (HMOs: 2′-fucosyllactose and lacto-N-neotetraose) and α-milk fat globule membrane (α-MFGM) are key bioactive components in human milk known to regulate intestinal...

Jian-Wei Wu, Zhen-Ye Shi, Jia-Yu Li et al. · Nutrients · 0 citations

#protein folding Review Open access Aug 2026

Toward Rational Design of Precision-Fermented Milk Proteins: Integrating Cross-Species Selection, Post-Translational Modification, and AI Optimization.

Milk proteins deliver nutritional, functional, and bioactive properties that alternative protein sources cannot adequately replicate, yet conventional livestock-based production faces compounding constraints of scalability, resource intensity, and sustainability. Precision fermentation offers a structurally distinct so...

Zhengtao Guo, Kun Ye, Zhen-Ye Shi et al. · Comprehensive Reviews in Foo... · 0 citations