Author

Zheng-Hong Zhang

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Review Open access Sep 2026

The Succinate–HIF-1α–NLRP3 Axis in 3-Nitropropionic Acid-Induced Ovarian Dysfunction: A Testable Metabolic–Inflammatory Framework

Simple Summary 3-Nitropropionic acid (3-NPA) is a mitochondrial toxin that inhibits succinate dehydrogenase and can cause reproductive and ovarian injury. Although direct studies have shown that 3-NPA exposure can increase oxidative stress, impair mitochondrial function, promote granulosa-cell apoptosis, disrupt follic...

Zheng-Hong Zhang, De-Fan Wang, Qing-He Lin et al. · Biology · 0 citations

Review Open access Aug 2026

The potential role of NLRP3 inflammasome in integrating redox, metabolic, and inflammatory signals during follicular development: a hypothesis-driven redox-metabolic integrator framework

A hypothesis-driven framework is proposed in which NLRP3 may act as a candidate redox-metabolic integrative node that coordinates stress-related signals within the follicular microenvironment and may contribute to developmental transitions including follicular growth, dominance acquisition, ovulatory competence, and at...

Zheng-Hong Zhang, De-Fan Wang, Qing-Qiang Lin et al. · Frontiers in Cell and Develo... · 0 citations