Role of mitochondria-associated endoplasmic reticulum membranes in hepatic ischemia-reperfusion injury: Molecular architecture, pathological remodeling, and therapeutic prospects.
A novel clinical strategy is proposed: targeting MAMs through a multi-level framework of "structural stabilization-calcium modulation-mitophagy restoration," delivered during perioperative windows such as organ preservation and machine perfusion, elevating MAMs from a mechanistic concept to a monitorable, stratifiable,...