Author

Zhengang Yang

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Open access Jul 2026

Delayed astrocyte development impairs Sema6a-Plxna2/4-mediated astrocyte-neuron crosstalk and causes depressive-like behavior

It is demonstrated that Egfr knockout during the critical period of neuronal maturation results in a transient absence of astrocytes, with recovery observed in adult mice, and developmental disruption of EGFR signaling leads to transient astrocyte loss and impaired astrocyte–neuron crosstalk.

Xin Jiang, Yanqing Qi, Lin Yang et al. · Nature Communications · 0 citations