AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Overall, compound 15 represents a promising BCL6 PROTAC degrader for DLBCL, which induced rapid and efficient BCL6 degradation in OCI-LY1 cells and displayed potent antiproliferative activity in BCL6-dependent DLBCL cells.
Summary Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and YTHDF proteins are frequently overexpressed in this malignancy, which correlates with adverse prognosis. Through high-throughput drug screening, we identify ellagic acid (EA) as a compound that binds to YTHDF proteins and disrupts thei...
KLHL12 is identified as a potentially tumor-selective E3 ligase and the development of the first-in-class KLHL12-recruiting PROTACs are reported, which established KLHL12 as a promising tumor‑selective E3 ligase and provided a KLHL12-recruiting PROTAC platform for cancer therapy.
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