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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Zheng-Xin Lai

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Open access Aug 2026

Integration of single-cell transcriptomics and genomic mutation analysis identifies an immunotherapy-resistant tumor subcluster and validates ARNTL2 as a malignant driver in lung adenocarcinoma

Highlights • Single-cell sequencing reveals resistance-linked malignant subcluster in LUAD.• Cluster 2 shows hyperproliferative reprogramming with KRT17, S100A2, CST6 upregulation.• CoxBoost + survivalSVM model achieves optimal C-index of 0.686 across seven cohorts.• Low-risk patients exhibit greater immune infiltratio...

Z. Qiu, Hui Zhao, Qiong Lyu et al. · 0 citations

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