Zheng-Rong Du

Parental genome reprogramming drives allelic convergence while preserving parent-of-origin memory during human early embryonic development.

Human sperm and oocytes carry highly distinct DNA methylation landscapes, yet parental DNA methylation ultimately converges to a largely equivalent state, raising the question of when and how the allelic DNA methylome is reprogrammed toward convergence. Here, we present an integrated allelic analysis of DNA methylation...