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Author

Zheng Guo

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Review Open access Aug 2026

Research progress and application prospects of multi-omics integration strategies in precision risk stratification of type 1 diabetes mellitus

This narrative review critically evaluates how multi-omics integration strategies can improve precision risk stratification throughout the T1D disease continuum by integrating complementary molecular information from genomics, transcriptomics, proteomics, proteomics, metabolomics, epigenomics, and the microbiome.

Zi-Yi Chen, Wen-Tao Liu, Zheng Guo et al. · 0 citations
Aug 2026

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery.

A dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of β cell-specific targeting ligands to enable selective gene delivery to pancreatic β cells is developed and establishes a versatile platform for RNA therapeutics and gene-editing applications in...

Di Yu, Yining Zhu, A. Roca-Rivada et al. · 1 citation

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