Ovarian cancer is the deadliest gynecological malignancy due to poor drug targeting, severe toxicity, and an immunosuppressive tumor microenvironment (TME). To address this, a pH/GSH dual-responsive bacterial-nanoparticle system (VNP@BD-Poly) based on attenuated Salmonella VNP20009 (VNP) was developed. A bovine serum a...
Living bacterial therapy offers strong tumor‐targeting and deep penetration into hypoxic regions, but its therapeutic potential is hindered by biosafety risks from bacterial proliferation after treatment. Herein, we designed a trigger‐destructive bacterial system that combines precise tumor targeting with controlla...
This study elucidated that a colloidal hydrogel loaded with decitabine (DAC) and crosslinked with lanthanum carbonate nanosheets (LCNSs) and gelatin nanoparticles (Gela NPs) could instigate pyroptosis in TNBC cells, specifically 4T1 cells and introduced an innovative paradigm for the immunotherapy of triple‐negative br...
Yang Hong, Haitao Wu, Weitao Wang et al.· Advancement of science· 0 citations
An intelligent nanoplatform-GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.)-based on reversible addition-fragmentation chain transfer (RAFT) polymerization technology is constructed, establishing a valuable technical framework for the development of multifunctional and stimuli-responsive nanomedicines.
Huai-Bin Yu, Zhuo-Rong Miao, Meng Wang et al.· ACS Applied Bio Materials· 0 citations
In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.
