Zhen-Zhen Ma

Autophagy-mediated amplification of ferroptosis via a curcumin-loaded metal-enzyme nanoplatform for synergistic tumor therapy.

In vitro and in vivo experiments demonstrate that the self-reinforcing cycle between autophagy and ferroptosis significantly enhances tumor suppression and suggests that targeting iron-autophagy crosstalk with nanomaterials represents a promising strategy for cancer treatment.