Zhen-Yu Wu

Forniceal deep brain stimulation improves memory in Rett syndrome mice by promoting the maturation of newborn hippocampal neurons.

Deep brain stimulation (DBS) is associated with an increase in hippocampal neurogenesis and memory benefits, but the causal mechanism is unclear. Here, we use a mouse model of Rett syndrome, a severe learning disability syndrome caused by MECP2 loss of function, to find that DBS promotes the maturation and integration...