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Zhen-Yu Feng

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Open access Sep 2026

The CMPK2–mtDNA axis mediates doxorubicin cardiotoxicity: mechanistic links to STAT1 transcription and FAD-mediated inhibition

Doxorubicin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity. The precise mechanisms bridging mitochondrial dysfunction to cardiac inflammatory responses remain poorly defined. We utilized cardiomyocyte-specific CMPK2 knockout and overexpression mou...

Zhen-Yu Feng, Li Lin, Yi-Jin Yang et al. · 0 citations

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