3q29 deletion (3q29Del) is a genetic risk variant for autism spectrum disorder and schizophrenia that often results in developmental delays, cognitive disability, and impaired fine motor function. People with 3q29Del have reduced cerebellar volume, which correlates with symptom severity, and many 3q29Del-associated phe...
May K. Kretzer, Elizabeth Arnulfo Candelario, R. Montalvo et al.· bioRxiv· 0 citations
Heart failure with reduced ejection fraction (HFrEF) remains a major cause of morbidity and mortality worldwide, characterized by impaired contractile function and mitochondrial dysfunction, yet therapies that simultaneously restore cardiac energetics and mechanical performance remain limited. Here, we show that adeno-...
Karthi Sreedevi, A. Doku, Alexey V. Zaitsev et al.· Research Square· 0 citations
Mustard keratopathy, caused by exposure of the cornea to sulfur or nitrogen mustard vesicants, chemical warfare agents, can lead to severe and often irreversible vision loss. Despite considerable efforts to develop medical countermeasures, including anti-inflammatory, antioxidant, anti-fibrotic, and anti-angiogenic the...
Arpan G. Mazumder, Evan Magarychoff, Hamid Alemi et al.· bioRxiv· 0 citations
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