Zhen Tian

Modeling macrophage-T cell interactions in the breast cancer immune microenvironment: from spatial omics to functional validation

Breast cancer immunity depends on more than the number of immune cells in a tumor. It is also shaped by where those cells sit, which neighbors they contact, and what functional states they adopt locally. Tumor-associated macrophages (TAMs) and T cells are a key pairing in this setting. Depending on tissue context, thei...