Zhen Ouyang

Structure-Guided Engineering of Xylitol 4-dehydrogenase Unlocks Efficient L-Xylulose Biosynthesis: Mechanistic Insights into Catalytic Enhancement

L-Xylulose, a potent α-glucosidase inhibitor and indispensable chiral precursor for L-nucleoside drugs, is highly valuable. However, chemical synthesis often suffers from poor atom economy and tedious protection and deprotection steps of functional groups. Here, a green biocatalytic route was explored by retrieving f...