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Zhen-Ni He

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Aug 2026

Polygalic acid produces rapid antidepressant effects via modulation of hippocampal inflammation and brain-derived neurotrophic factor expression in mice.

It is demonstrated that polygalic acid produces ketamine-like rapid antidepressant effects specifically through the resolution of chronic neuroinflammatory dysregulation and BDNF restoration, however, the presence of acute inflammatory activation nullifies its therapeutic efficacy, establishing neuroinflammatory contex...

Jinjin Xie, Jie Dong, Hai-Xiu Liao et al. · 0 citations

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