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Oct 2026

Molecular Diversity Generation via Selective Enzymatic C–CN Bond Scission

Selective removal of functional groups offers a powerful route to streamline molecular design and generate structural diversity. The use of such deletion strategies has surged in organic synthesis, yet achieving these transformations with high selectivity remains a formidable challenge. Here, we present a photoenzyma...

Qing-Qing Zeng, Xin-Cheng Yang, Bai-Xu Ma et al. · 0 citations
Sep 2026

Scalable Total Syntheses of Nonthmicin and Ecteinamycin Reveal a Dual Antibacterial and Antitoxin Profile against Clostridioides difficile

Clostridioides difficile infection (CDI) is a severe diarrheal disease with substantial mortality, frequent recurrence, and limited treatment options. Here, we describe a scalable total synthesis of ecteinamycin, a polyether ionophore with anti-C. difficile activity, and its congener nonthmicin. Key steps include two...

Xian-Xu Wang, Jian-Hua Luo, Bin Wang et al. · 0 citations

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