Aug 2026
YTHDF1-mediated translational activation of SETD2 suppresses aerobic glycolysis and sensitizes renal cell carcinoma to sunitinib.
The findings identify the YTHDF1/SETD2/p53 axis as a critical translational-epigenetic-metabolic relay, providing a compelling rationale for leveraging epitranscriptomic machineries to improve therapeutic sensitivity in advanced renal cancer.
Si-Wei Xu, Bizhen Huang, Hai Lin et al.
· Cellular Signalling · 0 citations