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Zhen-Hao Zhao

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Open access Sep 2026

HOTAIR Promotes Prostate Cancer Progression by facilitating CDK9-Pol II Association and Transcriptional Elongation

Previous research has predominantly focused on the regulatory role of lncRNA HOTAIR in gene silencing by interacting with the Polycomb repressive complex 2 (PRC2), but its direct role as a transcriptional activator remains less well characterized. Here, our study reveals a novel regulatory mechanism of HOTAIR, which fa...

Yu-Yang Qian, Bo Wang, Guang-Song Su et al. · 0 citations
Open access Sep 2026

A prostate cancer-specific super-enhancer at 1q42.3 regulates the CAPN2 and KRT19.

The findings provide insights into a functional epigenetic element within a classic genetic risk locus, proposing a mechanism by which super-enhancer-mediated regulation promotes prostate cancer progression.

Zhen-Hao Zhao, Yun-Long Bai, Qin Wang et al. · 0 citations

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