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Author

Zhen-Guo Chen

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Open access Oct 2026

Receptor-induced activation of MERS-CoV spike revealed by time-course cryo-EM

The Middle East respiratory syndrome coronavirus (MERS-CoV) initiates infection by engaging its host receptor dipeptidyl peptidase 4 (DPP4), which activates the viral spike (S) glycoprotein. However, how receptor binding is structurally coupled to membrane fusion has remained unclear. Here, using cryo–electron microsco...

Ya-Jie Wang, Xi-Yuan Pan, Yuxuan Jiang et al. · 0 citations
Open access Aug 2026

Enteric α-defensins contribute to intestinal mucosal immunity against SARS-CoV-2 infection.

It is suggested that enteric α-defensins help alleviate, as host protective factors, Covid-19 symptoms in the intestine despite higher ACE2 expression in the gut than in the lungs, and that Crp5 may be developed as a broad-spectrum antiviral for the treatment of coronavirus infection irrespective of virus type and vari...

Yilin Yang, Qianxi Yang, Xin Huang et al. · 0 citations
Aug 2026

Cryo-EM structure of the WDR11-FAM91A1-C17orf75 complex involved in retrograde trafficking.

Functional analyses demonstrate that C17orf75 is indispensable for the proper intracellular localization of the acidic-cluster-containing cargo proteins CI-MPR, KIAA0319L, and VAMP4 and establish C17orf75 as an integral component of the WFC complex in endosome-to-TGN trafficking.

Yifan Zhang, Zhi-Min Liu, Zi-Rong Chen et al. · 1 citation

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