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Author

Zhen Gu

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Sep 2026

Engineered cryo-shocked tumor cells recruit T cells for lung cancer immunotherapy.

Immune checkpoint blockade has transformed cancer therapy, yet its efficacy against solid tumors remains constrained by poor T cell infiltration and an immunosuppressive tumor microenvironment. Achieving localized and sustained chemokine signaling without systemic immune toxicity remains a central unmet challenge for c...

Hui-Heng Feng, Feng Liu, Ze-Sheng Cheng et al. · 0 citations
Open access Aug 2026

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

An efficient Cas9d system (Cas9dUltra) is developed through gRNA and protein engineering, and its base editors (9dBEs) further developed through gRNA and protein engineering, enabling efficient and precise genome editing in human cells.

Qingquan Xiao, Zhijin Tian, Luqi Weng et al. · 0 citations

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