Zhen Cheng

Radiopharmaceuticals for Melanoma Theranostics.

Design and Biological Evaluation of FAP-Man, a Mannosylated FAP-Targeted Radioglycopeptide for Tumor Imaging and Radionuclide Therapy

Fibroblast activation protein (FAP) is an attractive target for radiotheranostic development because of its abundant expression in tumor-associated fibroblasts and limited distribution in normal tissues. Here, we developed FAP-Man, a mannosylated FAP-targeted radioglycopeptide based on the FAP-2286 scaffold, to optim...

cRGD-Functionalized Calcium Carbonate Nanoprobe for Enhanced NIR-II Fluorescence Imaging and Tumor-Targeted Navigation.

A tumor-targeted nanoprobe is engineered by encapsulating ICG within a calcium carbonate core, followed by surface functionalization with phospholipids and cyclic RGD (cRGD) peptides, which exhibited remarkable tumor-targeting ability across other tumor models (U87, 4T1).

NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.

This review provides the first comprehensive focus on the combined application of NIR-mediated PTT/PDT with gas therapy (GT), chemodynamic therapy (CDT), immunotherapy, antibiotic adjuvants, and sonodynamic therapy (SDT), and highlights the current challenges and prospects for clinical translation.