Anti-inflammatory limonoids from Swietenia macrophylla seeds attenuate IL-1β release via NLRP3 inflammasome inhibition.
Seeds of Swietenia macrophylla are recognized as a beneficial dietary supplement due to their pronounced hypoglycemic and hypotensive properties. To explore the pharmaceutical potential of this plant, eight previously undescribed mexicanolide- and phragmalin-type limonoids (1-8), together with twenty known analogues (9...