Zhaodong Ai

Bidirectional regulation between ferroptosis and tumor-associated macrophages: mechanisms, strategies, and therapeutic perspectives

Ferroptosis arises when iron-dependent phospholipid peroxidation overwhelms the system xc−–glutathione–GPX4 axis and parallel antioxidant defenses. Within tumors, however, the immune consequence of this death process depends on how iron and oxidized material move between malignant and immune compartments. Tumor-associa...