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Zhao-Meng Cai

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Open access Jul 2026

Identification of a FoxP3-specific small molecule degrader with potent antitumor immunotherapeutic efficacy 2309510

The first FoxP3-specific small molecule degrader which promotes proteasomal degradation of FoxP3 and partially reduces Treg suppressive function is reported, demonstrating proof-of-concept and feasibility of targeting FoxP3, which has been known to be “undruggable”, in a chemical manner by small molecules.

Amy Y. Tang, Zhao-Meng Cai, Kun Liu et al. · 0 citations

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