FFAs secreted by A1 astrocytes contribute to RGCs apoptosis via PERK/eIF2α/ATF4/CHOP pathway in retinal ischemia/reperfusion injury.
PURPOSE To explore the specific mechanisms of retinal neuronal apoptosis induced by A1 polarization of astrocytes under retinal ischemia/reperfusion (RI/R) injury. METHODS 1) In vivo, SD rats were selected for acute intraocular hypertension (AIH) model. In vitro, A1 astrocytes model was induced by the tumor necrosis...