Zhao-Hui Guo

Discovery of oxazole-capped 4-phenoxypiperidine CSF1R type II inhibitors with potent in vivo anti-rheumatoid arthritis activity.

Colony-stimulating factor 1 receptor (CSF-1R) is a key target for regulating macrophage function and mediating the inflammatory response. Blocking CSF-1/CSF-1R signaling pathway and its downstream AKT cascade can effectively inhibit the release of downstream proinflammatory cytokines, which provides a promising therape...