Zhao-Heng Xie

Multi-GPU parallel framework for DOI-enabled long axial field-of-view PET image reconstruction.

Objective.Depth-of-interaction (DOI)-enabled long axial field-of-view (LAFOV) PET can mitigate parallax-induced resolution degradation, but DOI modeling substantially expands the lines-of-response (LOR) space and increases computational cost. This study aims to develop a scalable reconstruction framework for DOI-enable...

Physics in Medicine & Biology

Learning-enhanced hybrid planar-SPECT dosimetry for voxel-level Monte Carlo dose estimation in radionuclide therapy

Objective. Quantitative imaging-based dosimetry is essential for optimizing [177Lu]Lu-DOTATATE peptide receptor radionuclide therapy, yet full multi-time-point (MTP) SPECT/CT is difficult to implement in routine clinical practice. This study proposes a hybrid planar-SPECT framework for organ-level time-integrated activ...