Aug 2026
An IRAK1-snRNA axis activates ATM to promote accurate repair within transcriptionally active chromatin.
Genomic integrity in transcriptionally active regions is pivotal for suppressing oncogenic mutations, yet the mechanisms that govern precise homologous recombination (HR) repair within these regions remain elusive. Here, we report that the IRAK1-spliceosome axis operates with small nuclear RNA (snRNA) as a central hub,...
Chen Nie, Wan-Chang Liu, Lei Zhang et al.
· Molecules and Cells · 0 citations