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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Zeyuan Ma

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#protein folding Open access Sep 2026

The fold-switching benchmark for multi-state structure prediction is 53% near-isomorphic: on the audited strict tier, AlphaFold2's two-state recovery is 0/23

Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...

Zeyuan Ma · 0 citations
#protein folding Open access Sep 2026

The fold-switching benchmark for multi-state structure prediction is 53% near-isomorphic: on the audited strict tier, AlphaFold2's two-state recovery is 0/23

Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...

Zeyuan Ma · 0 citations
#protein folding Open access Sep 2026

The fold-switching benchmark for multi-state structure prediction is 53% near-isomorphic: on the audited strict tier, AlphaFold2's two-state recovery is 0/23

Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...

Zeyuan Ma · 0 citations

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