Author

Zengpeng Han

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Open access Aug 2026

Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo

Microglia play key roles in brain development, homeostasis, and neurodegeneration. Although multiple strategies for viral gene delivery to microglia have been reported, they have not been directly compared. Here, we developed microglia-targeting AAV capsids and benchmarked them against existing approaches. The novel ca...

Saša Jereb, Lia R. D’Alessandro, Nader Morshed et al. · bioRxiv · 0 citations

Open access Jul 2026

StitchR-based dual-AAV delivery strategies enable efficient transduction of defined neural cell populations

Four StitchR-based dual-viral reconstitution strategies by combining high-efficiency AAV serotypes with neuron- or glia-specific promoters expand the valuable AAV toolbox and offer crucial technical support for targeted delivery of large transgenes to defined neural cell populations, holding great significance for basi...

Nengsong Luo, Yunling Gao, Zengpeng Han et al. · Molecular Brain · 0 citations