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Review Open access Oct 2026

Immune checkpoint inhibitors combined with VEGF/VEGFR-targeted therapy in microsatellite-stable advanced colorectal cancer: clinical advances and the potential for immune-sensitive tumor conversion

Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality worldwide, and mismatch repair-proficient/microsatellite-stable (pMMR/MSS) tumors account for the majority of metastatic CRC cases. In contrast to dMMR/MSI-H CRC, pMMR/MSS tumors are typically characterized by low immunogenicity, li...

R. Wang, Xiao-Fang Zhou, Mei-Qin Yuan et al. · 0 citations
Open access Jul 2026

Axitinib promotes stemness and vasculogenic mimicry in triple-negative breast cancer by disrupting THBS1-CD47 axis-mediated endothelial-tumor cell communication

Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. Although anti-angiogenic agents like Axitinib are used in cancers, resistance emerges through poorly understood mechanisms involving stemness and vasculogenic mimicry (VM). Here, we investigated the regulatory role of thromb...

L. Lei, Huanhuan Zhou, Xiaojing Lai et al. · 0 citations

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