Quantification of somatic copy-number alterations to predict malignant transformation of oral leukoplakia: A prospective cohort study.
OBJECTIVE This study aimed to evaluate the predictive value of a quantitative index measuring the extent of somatic copy-number alteration (SCNA) for malignant transformation (MT) in oral leukoplakia (OLK). METHODS A prospective cohort of 122 patients with OLK was followed for a median of 74 months. Whole-exome seque...